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Senior Scientist, Respiratory Discovery (Biology & Translational Models)

Merck

South San Francisco, CA, United States Full-time July 25, 2026
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Vacancy Description

**Job Description**

The Senior Scientist will join the Respiratory Biology Discovery group and contribute to target identification, target validation, translational biology, and mechanism-of-action studies supporting early discovery programs across chronic lung diseases, including COPD, bronchiectasis, asthma, pulmonary fibrosis, and inflammatory airway disorders.

The successful candidate will leverage advanced human-relevant in vitro, ex vivo, and tissue-engineered model systems to generate mechanistic and translational datasets that inform target prioritization and therapeutic strategy. Expertise in primary airway and alveolar epithelial biology, multicellular disease models, epithelial-stromal-immune interactions, tissue remodeling, regeneration, and biomarker discovery is highly desirable. The scientist will collaborate closely with multidisciplinary teams spanning biology, bioengineering, computational biology, translational sciences, and clinical research.
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