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Research Scientist

Pentangle Tech Services | P5 Group

wilmington, de, United-States Full-time June 11, 2026
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Vacancy Description

Position Overview

We are seeking a highly skilled Sr. Research Scientist – Biochemistry to support drug discovery efforts through the design, development, and execution of biochemical and biophysical assays. This role will play a critical part in hit identification, validation, and mechanistic studies for small molecules and other therapeutic modalities.


Key Responsibilities

  • Design, develop, and execute biochemical assays (e.g., FI, HTRF, FP) and biophysical assays (e.g., SPR, BLI, ITC, DSF)
  • Conduct high-throughput screening (HTS) to evaluate compound libraries and characterize binding kinetics (IC₅₀, Kd, kon, koff)
  • Troubleshoot assay performance, optimizing for robustness, reproducibility, and scalability
  • Analyze and interpret experimental data using tools such as GraphPad Prism and Genedata
  • Support protein expression and purification workflows using chroma...

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