Postdoctoral fellowship in engineering hyper-recombinogenic streptomyces strains for biosynthetic pathway diversification and discovery of novel bioactive molecules

DESCRIPTION

Engineering Hyper-Recombinogenic Streptomyces Strains for Biosynthetic Pathway Diversification and Discovery of Novel Bioactive Molecules

Project: DIAMS (Diversification of the Specialized Metabolite Synthesis Arsenal in Streptomyces via Recombination Modulation)

Project Background

The discovery of new bioactive molecules remains a major challenge for addressing emerging needs in human health, biotechnology, and sustainable industrial processes. Members of the genus are among the most prolific producers of specialized metabolites, including antibiotics, anticancer agents, immunosuppressants, and industrially relevant enzymes.

Recent genomic studies have revealed that Streptomyces genomes harbor up to 40 biosynthetic gene clusters (BGCs), many of which remain cryptic or poorly characterized. In parallel, recent work from our laboratory demonstrated that conjugation-mediated large-scale chromosomal transfer can gene...