Doctoral Fellow: Accelerating Enzyme Evolution for Chemical Development: Intelligent Navigation[...]

Doctoral Marie Curie Fellow: Accelerating Enzyme Evolution for Chemical Development: Intelligent Navigation of the Sequence Space – 3‑year fixed term contract

Location: The Discovery Centre, Cambridge Biomedical Campus, Cambridge, UK

Salary: £40,000 gross (subject to deductions in line with UK policy) plus benefit fund and bonus.

Purpose of the role: A doctoral position is available for three years to work with AstraZeneca (Pharmaceutical Sciences, Early Chemical Development, Biocatalysis Team) and Professor Florian Hollfelder at the Biochemistry Department of Cambridge University. The project aims to accelerate enzyme discovery for biocatalytic applications using functional metagenomics, directed evolution, droplet microfluidics, next‑generation sequencing and machine learning. It is part of the Horizon Europe EU MarieCurie Network MetaExplore.

Key responsibilities

• Experimentally: generate and screen large and diverse DNA libraries with ...